St Johns Wort is a moderate-risk supplementwith an RDA of 300 mg and a safe upper limit (UL) of 900 mg per day according to EFSA standards. All 1 regional standards agree on these limits. It has 1 known interaction with other supplements including antidepressants. Use NutriAudit to check if your supplement stack keeps this ingredient within safe limits.
St Johns Wort sits in the Other Supplements category. This page consolidates 1 regional standard, and the numbers are broadly aligned, so the bigger question is whether your total dose stays in range.
It also has 1 known interaction, so the question is not just the label dose but whether the rest of your stack adds extra risk.
| Region | Organization | RDA | Upper Limit (UL) | Unit |
|---|---|---|---|---|
| 🇪🇺 Europe | EFSA | 300 | 900 | mg |
RDA = Recommended Daily Allowance (adequate intake for most adults). UL = Tolerable Upper Intake Level (maximum safe daily amount).
St. John's Wort may interact with antidepressants, causing serotonin syndrome.
Consult a doctor before combining with antidepressants.
First match your product label against the dose table above, then check whether the known interaction list includes anything in your current stack.
If you are taking multiple supplements, the safest approach is usually to audit the whole stack instead of judging a single bottle in isolation.
The safe upper limit (UL) for St Johns Wort is 900mg per day according to EFSA. Exceeding this amount regularly may increase the risk of adverse effects.
The RDA for St Johns Wort is 300mg per day for most adults. This amount is sufficient to meet the needs of 97-98% of healthy individuals.
Yes, St Johns Wort has 1 known interaction with other supplements. St. John's Wort may interact with antidepressants, causing serotonin syndrome.
Check if your supplement stack keeps St Johns Wort within safe limits.
Audit My SupplementsDisclaimer: NutriAudit is a decision-support tool designed to help you review your supplement stack for potential duplicate, conflicting, or excessive ingredients. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making changes to your supplement routine, especially if you are pregnant, nursing, taking medications, or have a medical condition.
Based on reference standards from FDA, EFSA, TGA, and MHLW.