High-dose niacin can cause uncomfortable flushing and, in severe cases, liver damage. Learn the difference between niacin flush and niacin toxicity, plus safe dosage limits.
High-dose niacin can cause flushing, liver enzyme changes, and other side effects.
| Standard | RDA | Upper Limit (UL) |
|---|---|---|
| US (FDA) | 16 mg | 35 mg |
| EU (EFSA) | 16 mg | 35 mg |
| AU (TGA) | 16 mg | 35 mg |
RDA = Recommended Dietary Allowance. UL = Tolerable Upper Intake Level. Exceeding the UL long-term may cause the toxicity symptoms described above.
Niacin flush (warmth, redness, itching) is generally harmless and temporary. However, sustained-release niacin at high doses can cause liver toxicity without the flush warning. The UL is 35 mg/day for nicotinic acid. Do not use high-dose niacin for cholesterol without medical supervision.
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Not medical advice. Always consult a qualified healthcare professional for personal medical decisions.