Different niacin forms can have different adverse-effect profiles. Review the form and combined label dose against a verified regional reference.
High-dose niacin can cause flushing, liver enzyme changes, and other side effects.
| Standard | RDA | Upper Limit (UL) |
|---|---|---|
| United States | 16 mg | 35 mg |
| European Union | 16 mg | 35 mg |
| Australia | 16 mg | 35 mg |
RDA = Recommended Dietary Allowance. UL = Tolerable Upper Intake Level. “Not established” does not mean unlimited intake is safe.
Niacin flush (warmth, redness, itching) is generally harmless and temporary. However, sustained-release niacin at high doses can cause liver toxicity without the flush warning. The UL is 35 mg/day for nicotinic acid. Do not use high-dose niacin for cholesterol without medical supervision.
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