Long-term high-dose vitamin B6 can cause peripheral neuropathy — numbness, tingling, and nerve damage. Learn the safe upper limits and why B6 toxicity is often overlooked.
Very high vitamin B6 for long periods can cause nerve-related symptoms.
| Standard | RDA | Upper Limit (UL) |
|---|---|---|
| US (FDA) | 1.7 mg | 100 mg |
| EU (EFSA) | 1.7 mg | 100 mg |
| AU (TGA) | 1.7 mg | 100 mg |
| CN (CNS) | 1.4 mg | 60 mg |
RDA = Recommended Dietary Allowance. UL = Tolerable Upper Intake Level. Exceeding the UL long-term may cause the toxicity symptoms described above.
Yes. Taking more than 100 mg/day of vitamin B6 for months or years can cause peripheral neuropathy — numbness, tingling, and pain in hands and feet. This is reversible if caught early. The UL is 100 mg/day, but most people only need 1.3-1.7 mg/day.
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Not medical advice. Always consult a qualified healthcare professional for personal medical decisions.